News RSS

Dietary supplements offer a myriad of health benefits, but it is important that what the research concerning a particular supplement is showing in vitro is what is actually occurring in humans in vivo. In order to make sure this occurs, it is important for the supplement to have high bioavailability, whereas many supplements are poorly bioavailable. The bioavailability of supplements depends on the molecular properties of the compound and the route of administration in the body. Bioavailability is the fraction of the drug or supplement that is given that will reach systemic circulation.   Methods of Administration For drugs and...

Read more

Tauroursodeoxycholic Acid (TUDCA) is a water soluble secondary bile acid that is found in large amounts in bear bile. In humans, trace amounts of TUDCA are formed when primary bile acids undergo bacterial metabolism to UDCA, and are then conjugated with Taurine to give TUDCA. TUDCA is a very promising molecule known for its ability to counteract regular bile acid toxicity in the liver, but also has many other beneficial effects. Another unique ability of TUDCA is its ability to prevent protein unfolding in the Endoplasmic Reticulum, reducing cell death. This ability is responsible for many of the benefits of...

Read more

Berberine is a quarternary ammonium salt (Figure 1) found in the roots, rhizomes, stems, and bark of plants such as Barberry (Berberis Vulgaris), Tree Turmeric (Berberis Aristata), Goldenseal (Hydrastis canadensis), and Oregon Grape (Mahonia Aquifolium). The use of berberine plant rich species such as the Berberis family has been used in Asia for over 3000 years1. Many clinical and experimental studies show that berberine has pharmacological properties such as immunomodulatory, antioxidative, cardioprotective, hepatoprotective, and renoprotective effects. In medicinal chemistry, the structure of Berberine has been modified to create bioactive derivatives in order to increase potency and selectivity2.    Figure 1:...

Read more

Chromium is an essential mineral that helps to regulate insulin. Chromium is a chemical element that commonly exists in the oxidation states: Cr6+, Cr3+, and Cr2+. In terms of a mineral for human consumption, Cr3+ (Trivalent Chromium) is the only oxidation state that has been shown to have beneficial effects. In fact, Cr6+ (Hexavalent Chromium) is a known carcinogen1. Trivalent Chromium is given in supplemental form as Chromium Chloride, Chromium Picolinate, Chromium Polynicotinate (otherwise known as niacin-bound Chromium), or Chromium GTF. Chromium Polynicotinate and Chromium Picolinate only differ in the spacing by the position of the nitrogen in the functional...

Read more

                                    Lion’s Mane (Hericium Erinaceus) is a medicinal mushroom with profound benefits. Lion’s Mane has  about 70 characterized actual and potential bioactive secondary metabolites to help as an antioxidant, anti-inflammatory, boosting the immune system, increasing cognitive health, neuroprotective, reducing anxiety and depression, heart health, aiding in digestion, wound healing, increasing nervous system recovery, and potential for treatment in diabetes, cancer, and various neurological disorders. The beneficial compounds found in Lion’s Mane range from polysaccharides (Beta-Glucans), aromatic compounds, terpenoids, diterpenes, sterols, fatty acids, and...

Read more